Inhibisi Senyawa Aktif Ekstrak Sirsak (Annona Muricata) Terhadap Pertumbuhan Plasmodium falciparum Berdasarkan Studi In Silico

Abstract

Abstract. Various active compounds in plants can be used as medicine. Soursop (Annona muricata) which grows in tropical areas such as Indonesia has potential as a new antimalarial drug. High resistance in the first-line artemisinin antimalarial treatment makes active compound of soursop a new antimalarial drug. This type of research is One Shot Experimental Study. This study analyzes preparation of active compounds, prediction of potential of active compounds, molecular docking, prediction of ADME (Absorption, Distribution, Metabolism, Excretion), and prediction of toxicity. Active compounds of soursop namely luteolin, anonaine, gallic acid, and acetogenin showed binding in the same area as artemisin in inhibiting β hydroxyacyl acyl carrier protein (ACP)-dehydratase (FabZ). The results of research on soursop have the potential as an antimalarial drug. Compounds acetogenin and luteolin have the highest binding affinity values. ADME and Lipinski soursop active compounds showed that luteolin, anonaine, and gallic acid had as good ADME as artemisinin, and had the potential to be used as oral drugs. Toxicity of soursop active compounds showed that luteolin and acetogenin had a better LD50 than control (artemisin) with toxicity classes 5 and 6, while anonaine and gallic acid had same LD50 as the control, with toxicity class 4.