Prevalensi Kejadian Aglutinasi Spermatozoa Rattus norvegicus Strain Wistar Albino yang Diberi Paparan Antibiotik Kanamycin

Muhammad Saka Abeiasa

doi:10.26740/jrba.v2n1.p1-5

Authors

Muhammad Saka Abeiasa Jurusan Keperawatan, Sekolah Tinggi Kesehatan Piala Sakti Pariaman

DOI:

https://doi.org/10.26740/jrba.v2n1.p1-5

Keywords:

aglutinasi, spermatozoa, antibiotik, kanamiycn

Abstract

Kelompok antibiotik dari golongan aminoglikosida seperti kanamycin dan gentamycin menyebabkan kesalahan penerjemahan dan efek inhibisi pada proses translokasi t-RNA dan m-RNA bakteri. Dilaporkan bahwa toksisitas kanamycin dapat meningkat seiring dengan peningkatan dosis yang diterima. Hal ini dapat berakibat penurunan jumlah dan kecacatan spermatozoa. Penelitian ini bertujuan untuk menguji pengaruh antibiotik kanamycin terhadap prevalensi kejadian aglutinasi spermatozoa. Jumlah aglutinasi spermatozoa dihitung menggunakan agglutination grade WHO. Penelitian ini merupakan penelitian eksperimental dengan model post-test-only control group design dengan variabel independen yaitu kanamycin dosis bertingkat dan variabel dependen yaitu jumlah aglutinasi spermatozoa. Data dianalisis menggunakan ANAVA dan dilanjutkan dengan uji lanjut Bonferroni. Hasil penelitian menunjukkan bahwa pemberian kanamycin dosis bertingkat berpengaruh terhadap prevalensi kejadian aglutinasi spermatozoa. Peningkatan jumlah aglutinasi seiring dengan peningkatan dosis yang diterima.

Author Biography

Muhammad Saka Abeiasa, Jurusan Keperawatan, Sekolah Tinggi Kesehatan Piala Sakti Pariaman

bimedical science (Reproduksi Kedokteran)

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