A Review of The Potential Marsilea crenata Presl. Leaves to Prevent Osteoporosis in Menopausal Women
Keywords:
Menopause, Osteoporosis, Marsilea crenata Presl. leaves, Isoflavone, EstrogenicAbstract
Women going through menopause often experience osteoporosis.
One preventive measure comes from herbal plants, especially those
containing isoflavones like Marsilea crenata Presl. leaves. This plant
was chosen because it has been proven as antioxidant, antiinflammatory,
and estrogenic effects that similar to natural
hormones. The aim of this study is to investigate the potential of
Marsilea crenata Presl. leaves as herbal therapy for preventing
osteoporosis. The study employs a literature review approach
collected from various scientific databases such as Science Direct,
PubMed, and Google Scholar. Articles were selected by exclusion
and inclusion criteria. The results indicate that isoflavones from
Marsilea crenata Presl. leaves interact with estrogen receptors,
helping to maintain balance between osteoblast and osteoclast
activity and reducing bone resorption. Based on in vitro and in vivo
studies, the isoflavones in Marsilea crenata Presl. leaves include
daidzein, genistein, biochanin A, and formononetin. In addition, the
antioxidant and anti-inflammatory properties of Marsilea crenata
Presl. leaves extract can enhance its therapeutic potential. A
comprehensive study explains the oral consumption of Marsilea
crenata Presl. leaves extract in postmenopausal women can increase
bone density and alleviate vasomotor symptoms
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