Difference Between Watermelon Juice and Pure L-citrulline on Muscle Soreness After Eccentric Exercise: A Comparative Study


  • Farah Fauziah Nandyantami Universitas Sebelas Maret Surakarta
  • Dhoni Akbar Ghozali Universitas Sebelas Maret
  • Siti Munawaroh Universitas Sebelas Maret Surakarta
  • Nanang Wiyono Universitas Sebelas Maret
  • Muthmainah Muthmainah University of Melbourne




Delayed-onset muscle soreness, muscle inflammation, uric acid, citrulline, watermelon juice


Muscle overuse during exercise increases the risk of muscle injury. L-citrulline, one of the ergogenic substances highly found in watermelon, is frequently used to reduce muscle soreness. This study aimed to compare the effects of pure L-citrulline and watermelon juice in reducing delayed-onset muscle soreness (DOMS) and muscle damage using uric acid as a marker for inflammation. A single-blind controlled trial was employed among 33 participants selected with a purposive sampling method. The participants were given either a mineral water drink containing 1.2 g of L-citrulline supplementation, 750 ml of watermelon juice, or a bottle of mineral water as a placebo administered 2-h before exercise. A multiple-sprint with a deceleration phase was used to induce DOMS. There was a significant decrease of DOMS 12 h and 24 h post-exercise with watermelon juice and pure L-citrulline (p=0.001). However, there was no significant difference in effectiveness between both forms of supplementation (p = 0.748). There were no significant changes in uric acid levels post-exercise with both forms of supplementation. Both watermelon juice and pure L-citrulline show similar effectiveness in improving subjective feelings of DOMS but fail to provide evidence of their ability to reduce muscle inflammation significantly via the reduction of uric acid levels.


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How to Cite

Nandyantami, F. F., Ghozali, D. A., Munawaroh, S., Wiyono, N., & Muthmainah, M. (2024). Difference Between Watermelon Juice and Pure L-citrulline on Muscle Soreness After Eccentric Exercise: A Comparative Study. JOSSAE (Journal of Sport Science and Education), 9(1), 8–17. https://doi.org/10.26740/jossae.v9n1.p8-17



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