The Increase of Brain-Derived Neurotrophic Factor Expression after Moderate-Intensity Aerobic Exercise in Obese Women


  • Rixco Gesang Gumelar Universitas Negeri Malang
  • Sugiharto Sugiharto Universitas Negeri Malang
  • Desiana Merawati Universitas Negeri Malang
  • Agnieszka Magdalena Nowak Jozef Pilsudski University of Physical Education in Warsaw
  • Adi Pranoto Universitas Airlangga



Aerobic exercise, BDNF expression, metabolic health, obesity


Obesity is closely related to a decrease in brain-derived neurotrophic factor (BDNF) expression, which will pose a risk for metabolic disorders. Therefore, this study aims to prove the effect of moderate-intensity aerobic exercise on increasing BDNF expression in obese women. A total of sixteen obese women were selected based on predetermined criteria and were divided into 2 groups, namely the aerobic exercise group (AE) and the control group (CN). Aerobic exercise was carried out by running on a treadmill at moderate intensity (60-70 HRmax) for 40 minutes/session with a frequency of 5x/week for 2 weeks. Blood samples were taken twice before and after exercise intervention to see BDNF expression using the Enzyme-Linked Immunosorbent Assay (ELISA-kit) method. The results of the analysis showed differences in increase between the control group (1816.66 ± 689.48 vs. 1822.86 ± 467.87 pg/mL; p = 0.974) and the intervention group (2173.81 ± 705.89 vs. 3635.01 ± 699.71 pg/mL; p = 0.013). This shows that moderate-intensity aerobic exercise carried out for 2 weeks has proven effective in increasing BDNF expression in obese women.


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How to Cite

Gumelar, R. G., Sugiharto, S., Merawati, D., Nowak, A. M., & Pranoto, A. (2024). The Increase of Brain-Derived Neurotrophic Factor Expression after Moderate-Intensity Aerobic Exercise in Obese Women. JOSSAE (Journal of Sport Science and Education), 9(1), 28–35.



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